You’ve all heard the story of the Trojan Horse and how the it was used to sneak soldiers in behind the gates of a walled city. Well with mercury detox we are doing essentially the same. We are using the principle of a liposome to sneak the powerful antioxidant glutathione into the bloodstream and ultimately past the cell walls to release it’s cargo.
Why a liposome? Well it is microscopic ball of fat molecules. That allows GSH which is protein to pass undigested into the bloodstream. Normal proteins like say steak, whey protein or GSH would just be digested into their component amino acids. The fat is just absorbed and not digested. Oil and water don’t mix you know. Now next once in the bloodstream the liposome can slowly release the glutathione into the bloodstream where it becomes a water soluble antioxidant. All good now. However not all opens up some is absorbed by the cell membranes allowing it pass through a second wall of defense. Fats will diffuse or be transported through that second wall too. Now the liposome can release it’s cargo inside the cell and attack the toxin, in this case mercury. So the trojan horse is what we are doing to bind intracellular mercury.
I recall reading a story about a lab scientist that spilled ethyl mercury onto her gloves and it absorbed through those into her bloodstream. Ultimately it migrated into her brain and she died in the hospital. Sad story for the lady and her family. But it got me thinking were her doctors dummies? Yes, possibly so. They gave her N acetylcysteine in the hopes that she would make her own glutathione from those ingredients to bind the mercury. They also give this for Tylenol (acetamenaphin) poisoning. However if all the enzymes needed to do the conversion in her brain were destroyed by the mercury she could not make the GSH herself. Yeah dummies indeed. The smarter solution would have been to also give her very high doses of intravenous and oral liposomal glutathione to get it into her brain to bind with the mercury. Arm chair quarterbacking yes I know but if someone is going to die anyways why not try it? Nothing to lose. It shows to me that medical personnel don’t really understand chemistry but only to prescribe pills that the pharma rep tells them to. Yeah we see this a lot. Take two and call me in the morning. No, one needs to fix the underlying problem. This is like the difference between a mechanic and an engineer. The mechanic merely replaces the fluids and parts. The engineer understands how the system works and what really is going on.
Ok off my high horse (pun intended) and back to our discussion. So as I was watching a tv advert that showed a trojan horse I thought hey that is a great analogy for what we are doing with mercury detox using liposomal glutathione. We want to get inside the city walls to slay the mercury and free the city. Go horsie
Here’s my original post on it. This method can also be a way to detox other toxins that bind with GSH.
So you might wonder how exactly we can detox mercury from the brain. Let’s look at what happens.
Inorganic mercury can accumulate in the brain, especially after elemental mercury vapor is inhaled and oxidized to Hg²⁺. Studies show that intracellular glutathione plays a protective role in neural cells exposed to inorganic mercury, helping maintain cell viability and buffering oxidative damage.However, the capacity of GSH to detoxify inorganic mercury is limited by its availability and synthesis rate. When GSH is depleted, mercury toxicity increases sharply.
Yes, this exactly what happens with dental mercury. You huff and inhale the vapor for years until the mercury builds up in your body and brain as the body’s defenses can no longer keep up. Then the build up begins and symptoms start (memory loss, sleep disturbances, tremor, poor concentration and coordination, emotional issues, allergies, bleeding gums, metallic taste in mouth).
Binding Potential: Inorganic mercury (Hg²⁺) has a strong affinity for thiol (-SH) groups, which are present in glutathione. Once inside brain cells, glutathione can form Hg–GSH complexes, helping to neutralize mercury’s reactivity and reduce oxidative stress. Sounds great. Now we just need to get the mercury into the brain cells.
Limitations of Delivery: Glutathione itself doesn’t cross the blood-brain barrier (BBB) efficiently. So simply ingesting it or injecting it won’t flood the brain with GSH. Some say amino acid precursors but I don’t think this works well as synthesis if impaired.
Why Liposomal Glutathione Matters:
Improved Absorption: Liposomes are tiny fat-based vesicles that protect glutathione from degradation in the gut and bloodstream, allowing more of it to reach cells intact. Once in circulation, liposomal glutathione can fuse with cell membranes or be taken up via endocytosis, delivering GSH directly into cells. While native glutathione struggles to cross the blood-brain barrier (BBB), liposomal formulations may improve delivery—especially if engineered to exploit glutathione transporters or receptor-mediated endocytosis. So we are going to cheat and bypass the blood brain barrier via liposomes to get glutathione directly into the brain to detox the mercury.
Can It Reach the Brain?
Transporter Targeting: The brain expresses a sodium-dependent glutathione transporter on its capillary endothelial cells, which can be leveraged for targeted delivery.
Experimental Success: Studies using glutathione-conjugated liposomes have shown increased brain uptake of drugs in animal models, suggesting that similar strategies could work for GSH itself. While promising, direct evidence of liposomal glutathione significantly raising intracellular GSH levels in human brain tissue is limited. Most data comes from preclinical models.Liposomal glutathione can enhance systemic and possibly brain delivery, especially if designed to exploit BBB transport mechanisms. Once inside brain cells, it can bind inorganic mercury and buffer oxidative stress.
There are a few compelling studies that suggest glutathione-coated liposomes—especially PEGylated ones—can cross the blood-brain barrier (BBB) and deliver cargo into brain tissue:
Glutathione PEGylated Liposomes in Rats ( this is a good study as it shows the crossing with tracer dye)
Study Design: Researchers used fluorescent tracers inside glutathione-PEG liposomes and tracked their distribution in rats.
Key Findings:
Uptake in rat brain endothelial cells was 1.8× higher than non-targeted liposomes. In vivo microdialysis showed 4× higher brain levels of the tracer after IV injection of GSH-PEG liposomes compared to controls.
Implication: Glutathione coating significantly enhances brain delivery, likely via transporter-mediated uptake.
Ok so this works in rats but this is how medical research is done. Basically rats a mammals have very similar biochemistry to humans. That’s why they call them lab rats. You know the white ones you see. We aren’t really allowed to experiment on people nowadays. That is frowned upon.
So here is my advice.
- Don’t ever get mercury dental amalgam fillings or allows your relatives, children or friends to get them
- Don’t eat lots of big fish as they can contain methyl mercury via bioaccumulation
- If you have the mercury amalgam fillings get them replaced with safer materials to reduce dosage and remove the input source. Once you have removed them you will feel better , allergies might alleviate and metallic taste in your mouth will be gone. I did this.
- Once you have had the fillings out for six months or more you can start detox with liposomal glutathione.
- As a you do the detox keep a notebook or spreadsheet of where you note observations. For me memories pop up that we long lost like from 30 years ago. Like very specific stuff like names, place items. That is how you know it is working. You will also feel mentally sharper.
Mr. Cash Hoarder 