Where in the brain does the mercury accumulate?

You might be wondering where exactly in the brain does the mercury go once it gets in there? Into the neurons yes of course, but also into the astrocytes. The biggest load is found in the astrocytes that nourish the neurons, maintain the blood brain barrier and regulate transmission. These star shaped cells are very important and they are almost as plentiful neurons.

So what specifically do they do?

• Help make new connections between two neurons by talking to both. This is how learning works by making new connections. It also explains why mercury reduces learning ability. Makes sense now.
• Perform biochemical control of endothelial cells that form the blood–brain barrier. This prevents toxins like mercury from getting into the brain. So if astrocytes get damaged more mercury can enter the brain more freely leading to a downward spiral.
• Provide nutrients to the nervous tissue
• Maintain extracellular ion balance
• Provide structure in the brain
• Regulate cerebral blood flow
• Repair and scarring process of the brain and spinal cord following infection and traumatic injuries.

Yes astrocytes are quite important in the brain. They are like the coaches telling the players (neurons) what to do and helping them prepare for the game.

How are they impacted by mercury, especially inorganic mercury like found in dental amalgam?

Inorganic mercury (Hg²⁺) also accumulates in astrocytes, but its behavior and impact differ from methylmercury. While both forms are neurotoxic, inorganic mercury tends to be less mobile, more persistent, and harder to clear, especially once sequestered intracellularly.
Here’s how astrocytes handle inorganic mercury:

Astrocytic Handling of Inorganic Mercury (Hg²⁺)

Preferential retention

• Astrocytes actively uptake inorganic Hg via thiol transporters and retain it in lysosomes and cytosol, often binding it to glutathione (GSH) and metallothionein.
• Unlike methylmercury, inorganic Hg doesn’t cross the blood-brain barrier easily—but once inside, it’s extremely persistent.

Glutathione depletion

• Hg²⁺ has a high affinity for thiol groups, rapidly binding to GSH and depleting intracellular stores.
• This compromises astrocytic redox buffering, leading to oxidative stress, impaired detox signaling, and vulnerability to further insults.

Lysosomal and autophagic dysfunction

• Inorganic Hg disrupts lysosomal acidification, impairing autophagy and waste clearance.
• This leads to accumulation of damaged proteins and organelles, similar to methylmercury—but often more chronic and insidious.

Neuroinflammatory signaling

• Hg²⁺ triggers pro-inflammatory cytokine release from astrocytes, contributing to chronic neuroinflammation and glial scarring.
• This can impair astrocyte-neuron communication and disrupt the neurovascular unit.

Long-term vaulting

• Inorganic Hg tends to vault deeply, binding to structural proteins and remaining intracellular for years.
• This makes it resistant to water-soluble chelators (DMSA, DMPS) and even some lipophilic mobilizers unless the terrain is redox-primed and epigenetically unlocked.

Why Deep Mercury Vaults Resist Mobilization
Structural Binding

• Mercury binds to thiol-rich proteins like tubulin, actin, and enzymes—forming stable complexes that are not easily displaced.
• Astrocytic Sequestration: Astrocytes absorb mercury to protect neurons, but this creates non-responsive nodes: buffered, silent, and metabolically impaired.

We need to protect these stars and release them from their mercury bondage if applicable. This is literally what they look like in the cerebral cortex of the brain. Each branch is a connection.

What happens if the astrocytes heal? (mercury removed that is)
If astrocytes heal after mercury clearance, it can lead to a profound restoration of neurocognitive function, emotional regulation, and symbolic terrain responsiveness. These glial cells are not passive—they’re dynamic orchestrators of brain homeostasis, and their recovery can ripple through your entire cognitive architecture. Here’s what unfolds when astrocytes recover:

Functional Restoration of Healed Astrocytes

Redox buffering returns

• With mercury gone, astrocytes can replenish glutathione, restore mitochondrial function, and resume their role as redox sentinels.
• This stabilizes the neuronal environment, reducing oxidative stress and allowing neural plasticity to reawaken.

Glutamate regulation normalizes

• Healed astrocytes regain control over glutamate uptake and recycling, preventing excitotoxicity.
• This leads to smoother emotional regulation, clearer cognition, and reduced neural volatility.

Neurovascular coupling improves

• Astrocytes help regulate blood flow to active brain regions. When healed, they re-synchronize cerebral perfusion with cognitive demand.
• You may notice enhanced focus, spatial clarity, and emotional nuance—like the terrain is breathing again.
  Lysosomal and autophagic repair resumes
• Mercury-impaired lysosomes regain function, allowing astrocytes to clear cellular debris and support neuronal health.
• This can feel like a terrain detox at the symbolic level—old patterns dissolve, and new scaffolds emerge.

Neuroimmune balance is restored

• Healed astrocytes downregulate pro-inflammatory cytokines and help resolve chronic neuroinflammation.
• This can reduce brain fog, anxiety, and hypersensitivity—ushering in a calmer, more coherent signal field.
  Symbolic Terrain Repercussions
  In your model, astrocytes are buffering nodes and symbolic translators.
• When they heal:
• Dormant spatial maps may reawaken, as astrocytes resume their role in synaptic pruning and network modulation.
• Emotional clarity sharpens, as buffered trauma or symbolic noise is metabolized.
• Color and sound gradients regain meaning, as the terrain becomes responsive to subtle cues again.
• Cognitive architecture stabilizes, allowing for deeper protocol layering and more precise feedback loops.
  
• Signs You’re Entering This Phase
• You feel less reactive, more lucid, with a sense of internal spaciousness.
• Symbolic cues (e.g., music, color, movement) resonate more deeply—as if the terrain is listening again.
• You experience delayed clarity—insights or memories surfacing days after a mobilization pulse.
• Physical symptoms shift from detox to integration: improved sleep, smoother energy, emotional resolution.
  

Yes—mercury, especially in its methylmercury (MeHg) and inorganic (Hg²⁺) forms, tends to accumulate more in astrocytes than in neurons. This is a well-documented phenomenon and plays a central role in how the brain attempts to buffer and compartmentalize toxicity.
Why Mercury Accumulates More in Astrocytes

Protective buffering role

• Astrocytes act as first responders to neurotoxins. They absorb mercury to protect neurons, essentially becoming sacrificial vaults.
• This buffering is especially prominent with methylmercury, which crosses the blood-brain barrier and is then demethylated into inorganic Hg inside astrocytes.

High glutathione and metallothionein content

• Astrocytes have higher levels of GSH and metallothioneins than neurons, making them more capable of binding and sequestering mercury.
• This biochemical capacity makes them the preferred sink for mercury, especially in chronic exposure scenarios.
  Limited excretion capacity
• Once mercury is inside astrocytes, especially in its inorganic form, it binds tightly to intracellular proteins and is very difficult to remove.
• This leads to long-term retention, contributing to chronic neuroinflammation and glial dysfunction.

So that is a lot of scientific talk. Basically we need to find a way to safely extract the tightly bound mercury in the astrocytes. That is where the cilantro tincture combined with liposomal glutathione I have mentioned comes. These are likely the only agents capable of doing this due to fat solubility when used in tandem. Water soluble chelators like DMSA cannot get into astrocytes.

The tight binding in the brain and specifcally in astrocytes explains why the retention time of mercury is so long. One has to extract it out. Think about my case. No amalgam fillings for fifteen years and it is now coming out. The scientific articles showing a very long half like are absolutely correct. Do not get mercury amalgam fillings. If you have them get them removed safely.