How Liposomal Mercury Detox Works

So you might wonder how exactly we can detox mercury from the brain. Let’s look at what happens.

Inorganic mercury can accumulate in the brain, especially after elemental mercury vapor is inhaled and oxidized to Hg²⁺. Studies show that intracellular glutathione plays a protective role in neural cells exposed to inorganic mercury, helping maintain cell viability and buffering oxidative damage.However, the capacity of GSH to detoxify inorganic mercury is limited by its availability and synthesis rate. When GSH is depleted, mercury toxicity increases sharply.

Yes, this exactly what happens with dental mercury. You huff and inhale the vapor for years until the mercury builds up in your body and brain as the body’s defenses can no longer keep up. Then the build up begins and symptoms start (memory loss, sleep disturbances, tremor, poor concentration and coordination, emotional issues, allergies, bleeding gums, metallic taste in mouth).

Binding Potential: Inorganic mercury (Hg²⁺) has a strong affinity for thiol (-SH) groups, which are present in glutathione. Once inside brain cells, glutathione can form Hg–GSH complexes, helping to neutralize mercury’s reactivity and reduce oxidative stress. Sounds great. Now we just need to get the mercury into the brain cells.

Limitations of Delivery: Glutathione itself doesn’t cross the blood-brain barrier (BBB) efficiently. So simply ingesting it or injecting it won’t flood the brain with GSH. Some say amino acid precursors but I don’t think this works well as synthesis if impaired.

Why Liposomal Glutathione Matters:

Improved Absorption: Liposomes are tiny fat-based vesicles that protect glutathione from degradation in the gut and bloodstream, allowing more of it to reach cells intact. Once in circulation, liposomal glutathione can fuse with cell membranes or be taken up via endocytosis, delivering GSH directly into cells. While native glutathione struggles to cross the blood-brain barrier (BBB), liposomal formulations may improve delivery—especially if engineered to exploit glutathione transporters or receptor-mediated endocytosis. So we are going to cheat and bypass the blood brain barrier via liposomes to get glutathione directly into the brain to detox the mercury.

Can It Reach the Brain?

Transporter Targeting: The brain expresses a sodium-dependent glutathione transporter on its capillary endothelial cells, which can be leveraged for targeted delivery.

Experimental Success: Studies using glutathione-conjugated liposomes have shown increased brain uptake of drugs in animal models, suggesting that similar strategies could work for GSH itself. While promising, direct evidence of liposomal glutathione significantly raising intracellular GSH levels in human brain tissue is limited. Most data comes from preclinical models.Liposomal glutathione can enhance systemic and possibly brain delivery, especially if designed to exploit BBB transport mechanisms. Once inside brain cells, it can bind inorganic mercury and buffer oxidative stress.

There are a few compelling studies that suggest glutathione-coated liposomes—especially PEGylated ones—can cross the blood-brain barrier (BBB) and deliver cargo into brain tissue:

Glutathione PEGylated Liposomes in Rats ( this is a good study as it shows the crossing with tracer dye)

Study Design: Researchers used fluorescent tracers inside glutathione-PEG liposomes and tracked their distribution in rats.

Key Findings:

Uptake in rat brain endothelial cells was 1.8× higher than non-targeted liposomes. In vivo microdialysis showed 4× higher brain levels of the tracer after IV injection of GSH-PEG liposomes compared to controls.

Implication: Glutathione coating significantly enhances brain delivery, likely via transporter-mediated uptake.

Ok so this works in rats but this is how medical research is done. Basically rats a mammals have very similar biochemistry to humans. That’s why they call them lab rats. You know the white ones you see. We aren’t really allowed to experiment on people nowadays. That is frowned upon.

So here is my advice.

• Don’t ever get mercury dental amalgam fillings or allows your relatives, children or friends to get them
• Don’t eat lots of big fish as they can contain methyl mercury via bioaccumulation
• If you have the mercury amalgam fillings get them replaced with safer materials to reduce dosage and remove the input source. Once you have removed them you will feel better , allergies might alleviate and metallic taste in your mouth will be gone. I did this.
• Once you have had the fillings out for six months or more you can start detox with liposomal glutathione.
• As a you do the detox keep a notebook or spreadsheet of where you note observations. For me memories pop up that we long lost like from 30 years ago. Like very specific stuff like names, place items. That is how you know it is working. You will also feel mentally sharper.